Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial (2024)

Abstract

Background: S-isomer (S) pantoprazole is known to be more effective and less dependent on cytochrome 2C19 than R-isomer (R)-pantoprazole. Aim: The purpose of this study was to compare the efficacy and safety of S-pantoprazole 20 mg versus pantoprazole 40 mg for treatment of reflux esophagitis. Methods: This multi-center, double-blind, randomized trial enrolled patients with endoscopically documented reflux esophagitis. Patients were assigned to receive either 20 mg S-pantoprazole or 40 mg pantoprazole once daily for 4 weeks. Endoscopy and symptoms were assessed after 4 weeks of treatment. In patients whose reflux esophagitis was not resolved at 4 weeks, treatment was extended to 8 weeks and symptoms were reassessed. Heartburn, chest pain, acid regurgitation, globus, and overall symptoms were rated. The primary efficacy endpoint was healing of esophagitis, and secondary endpoints were symptomatic and endoscopic improvement. Results: Sixty-seven patients in the S-pantoprazole group (52 male, mean age 51 years) and 62 in the pantoprazole group (61 male, mean age 50 years) were analyzed per protocol. The healing rate of reflux esophagitis was 85 % at 4 weeks and 94 % at 8 weeks in the S-pantoprazole group, which did not differ from those in the pantoprazole group (84 and 97 %, respectively). After treatment, individual and overall gastroesophageal reflux disease (GERD) symptoms and esophagitis improved compared with baseline inflammation in both groups. Intergroup differences in symptoms and endoscopic healing were not significant. Conclusion: The efficacy and safety of 20 mg S-pantoprazole were comparable to those of 40 mg pantoprazole for treatment of reflux esophagitis and symptomatic improvement of GERD.

Original languageEnglish
Pages (from-to)3189-3194
Number of pages6
JournalDigestive Diseases and Sciences
Volume57
Issue number12
DOIs
Publication statusPublished - 2012 Dec 1

Keywords

  • Efficacy
  • Enantiomer
  • Pantoprazole
  • Proton pump inhibitor
  • Racemate

ASJC Scopus subject areas

  • Gastroenterology
  • Physiology

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Cho, Y. K., Choi, M. G., Bak, Y.-T., Rhee, P. L., Kim, S. G., Jung, H. Y., & Seol, S. Y. (2012). Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial. Digestive Diseases and Sciences, 57(12), 3189-3194. https://doi.org/10.1007/s10620-012-2297-y

Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial. / Cho, Yu Kyung; Choi, Myung Gyu; Bak, Young-Tae et al.
In: Digestive Diseases and Sciences, Vol. 57, No. 12, 01.12.2012, p. 3189-3194.

Research output: Contribution to journalArticlepeer-review

Cho, YK, Choi, MG, Bak, Y-T, Rhee, PL, Kim, SG, Jung, HY & Seol, SY 2012, 'Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial', Digestive Diseases and Sciences, vol. 57, no. 12, pp. 3189-3194. https://doi.org/10.1007/s10620-012-2297-y

Cho YK, Choi MG, Bak YT, Rhee PL, Kim SG, Jung HY et al. Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial. Digestive Diseases and Sciences. 2012 Dec 1;57(12):3189-3194. doi: 10.1007/s10620-012-2297-y

Cho, Yu Kyung ; Choi, Myung Gyu ; Bak, Young-Tae et al. / Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis : A randomized, double-blind comparative trial. In: Digestive Diseases and Sciences. 2012 ; Vol. 57, No. 12. pp. 3189-3194.

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title = "Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial",

abstract = "Background: S-isomer (S) pantoprazole is known to be more effective and less dependent on cytochrome 2C19 than R-isomer (R)-pantoprazole. Aim: The purpose of this study was to compare the efficacy and safety of S-pantoprazole 20 mg versus pantoprazole 40 mg for treatment of reflux esophagitis. Methods: This multi-center, double-blind, randomized trial enrolled patients with endoscopically documented reflux esophagitis. Patients were assigned to receive either 20 mg S-pantoprazole or 40 mg pantoprazole once daily for 4 weeks. Endoscopy and symptoms were assessed after 4 weeks of treatment. In patients whose reflux esophagitis was not resolved at 4 weeks, treatment was extended to 8 weeks and symptoms were reassessed. Heartburn, chest pain, acid regurgitation, globus, and overall symptoms were rated. The primary efficacy endpoint was healing of esophagitis, and secondary endpoints were symptomatic and endoscopic improvement. Results: Sixty-seven patients in the S-pantoprazole group (52 male, mean age 51 years) and 62 in the pantoprazole group (61 male, mean age 50 years) were analyzed per protocol. The healing rate of reflux esophagitis was 85 % at 4 weeks and 94 % at 8 weeks in the S-pantoprazole group, which did not differ from those in the pantoprazole group (84 and 97 %, respectively). After treatment, individual and overall gastroesophageal reflux disease (GERD) symptoms and esophagitis improved compared with baseline inflammation in both groups. Intergroup differences in symptoms and endoscopic healing were not significant. Conclusion: The efficacy and safety of 20 mg S-pantoprazole were comparable to those of 40 mg pantoprazole for treatment of reflux esophagitis and symptomatic improvement of GERD.",

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Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial (2024)

FAQs

Efficacy of S-pantoprazole 20 mg compared with pantoprazole 40 mg in the treatment of reflux esophagitis: A randomized, double-blind comparative trial? ›

Conclusion The efficacy and safety of 20 mg S-pantoprazole were comparable to those of 40 mg pantoprazole for treatment of reflux esophagitis and symptomatic improvement of GERD.

What is the difference between pantoprazole and pantoprazole magnesium 40 mg? ›

Pantoprazole magnesium (pantoprazole-Mg) has a longer elimination half-life than pantoprazole sodium (pantoprazole-Na), resulting in prolonged drug exposure.

Is 20 mg pantoprazole better than 40 mg? ›

Conclusions: Both the 20 mg and 40 mg doses of pantoprazole are safe and effective in maintaining patients with healed reflux oesophagitis in remission. Moreover, for the majority of patients, the 20 mg dose provides adequate long-term therapeutic efficacy at a minimal drug exposure and lower costs.

What is the difference between pan 20 and pan 40? ›

Q: Pan 40 vs Pan 20, are they the same? A: Pantoprazole is the active ingredient in both Pan 40 and Pan 20, but the concentrations differ. Pan 40 contains 40 mg of Pantoprazole, while Pan 20 contains 20 mg. They are used to reduce stomach acid production in conditions such as GERD and gastric ulcers.

What is the efficacy of pantoprazole? ›

98.4% of patients receiving pantoprazole for 4 weeks experienced significant relief of leading symptoms with the average score of 1.11. 93.6% of patients reported average leading symptom severity score of 0.54 after 8 weeks of treatment.

What is the over the counter equivalent of pantoprazole 40 mg? ›

There is no Protonix over-the-counter (OTC) version available. Other OTC drugs may be similar to Protonix. Prilosec OTC, Nexium 24HR and Prevacid 24HR are available over the counter. The generic name for Protonix is pantoprazole.

Is pantoprazole 40 mg good for acid reflux? ›

Pantoprazole reduces the amount of acid your stomach makes. It's used for heartburn, acid reflux and gastro-oesophageal reflux disease (GORD) – GORD is when you keep getting acid reflux. It's also taken to prevent and treat stomach ulcers.

What is the safest acid reflux medication for long-term use? ›

PPIs are considered the better option if you have chronic (long-lasting) issues with stomach acid production.

What is the best prescription medication for acid reflux? ›

Prescription medicines

Prescription-strength treatments for GERD include: Prescription-strength proton pump inhibitors. These include esomeprazole (Nexium), lansoprazole (Prevacid), omeprazole (Prilosec), pantoprazole (Protonix), rabeprazole (Aciphex) and dexlansoprazole (Dexilant).

Can I take 2 20mg pantoprazole instead of 1 40mg? ›

Swallow PROTONIX Delayed-Release Tablets whole, with or without food in the stomach. For patients unable to swallow a 40 mg tablet, two 20 mg tablets may be taken.

Is it better to take pan 40 in the morning or at night? ›

Directions for Use of Pan 40 MG

The medicine must be taken 1 hour before food, on an empty stomach. You should not consume it more than that prescribed by your doctor.

Who should not take pan 40? ›

You should avoid taking PAN 40 Tablet if you are allergic to PAN 40 Tablet or proton pump inhibitors, have gastric cancer, liver disease, low magnesium level (osteoporosis), low vitamin B12, pregnant or planning for pregnancy and breastfeeding mothers.

Can I take pantoprazole at night after dinner? ›

Pantoprazole is usually taken once a day, on an empty stomach or with/after food. However, it can also be taken twice a day, once in the morning and the evening. This medication begins to show its effect within two to three days.

What is a safer alternative to pantoprazole? ›

The following are some of the most common alternatives to pantoprazole.
  • Omeprazole (Prilosec) Omeprazole is one of the most commonly used PPIs and works just like pantoprazole to lower stomach acid secretion. ...
  • Esomeprazole (Nexium) ...
  • Lansoprazole (Prevacid) ...
  • Dexlansoprazole (Dexilant) ...
  • Rabeprazole (Aciphex)
Aug 14, 2023

Which is more effective omeprazole or pantoprazole? ›

Generally, pantoprazole and omeprazole are equally effective. Studies comparing pantoprazole and omeprazole have found pantoprazole as effective as omeprazole in treating GERD as well as treating stomach ulcers. ScriptSave WellRx can help you save on your prescription medication costs.

Why is pantoprazole not recommended for long term use? ›

Long-term PPI use has been associated with an increased risk of several adverse outcomes in observational studies, including bone fractures, vitamin B12, magnesium or iron deficiency, Clostridium difficile infection and community-acquired pneumonia.

Are there different types of pantoprazole? ›

Pantoprazole oral tablet is available as both a generic and a brand-name drug. Brand name: Protonix. Pantoprazole comes in three forms: a delayed-release oral tablet, a delayed-release oral liquid suspension, and an intravenous (IV) form that's injected into a vein by a healthcare professional.

Does pantoprazole magnesium cause weight gain? ›

You may have weight gain while you're taking pantoprazole oral tablets. Both weight gain and weight loss were reported after the drug's initial studies were done. Additionally, you may gain weight if you have edema (swelling) or bloating, which are possible side effects of pantoprazole.

What is the other name for pantoprazole magnesium? ›

Both Pantoloc and Tecta belong to a family of medications called proton pump inhibitors, or PPIs. These medications are designed to help reduce the amount of acid that is produced in a person's stomach. While Pantoloc also goes by the generic name pantoprazole sodium, the Tecta generic name is pantoprazole magnesium.

What is Teva pantoprazole magnesium 40 mg used for? ›

Pantoprazole is used to treat certain conditions in which there is too much acid in the stomach. It is used to treat erosive esophagitis or "heartburn" caused by gastroesophageal reflux disease (GERD), a condition where the acid in the stomach washes back up into the esophagus.

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